Below is a rogue's gallery of the molecules discovered for the first time in the interstellar medium by the McGuire group and its members.

Structure of cyanocoronene

C24H11CN

Wenzel et al. 2025

Common Name: Cyanocoronene
Year Discovered: 2025
Source: TMC-1
Telescope: GBT
Fun Fact: Largest interstellar molecule detected using radio astronomy.

Structure of 3-hydroxypropanal

HOCH2CH2CHO

Fried et al. 2025

Common Name: 3-hydroxypropanal
Year Discovered: 2025
Source: G+0.693-0.027
Telescope: Yebes 40m Telescope and IRAM 30m Telescope
Fun Fact: Tentative detection. 3-hydroxypropanal is one of six C3H6O2 isomers detected toward G+0.693-0.027

Structure of 4-cyanopyrene

4-C16H9CN

Wenzel et al. 2025

Common Name: 4-cyanopyrene
Year Discovered: 2025
Source: TMC-1
Telescope: GBT
Fun Fact: It is estimated that pyrene contains up to 0.1% of the carbon in TMC-1.

Structure of 2-cyanopyrene

2-C16H9CN

Wenzel et al. 2025

Common Name: 2-cyanopyrene
Year Discovered: 2025
Source: TMC-1
Telescope: GBT
Fun Fact: It is estimated that pyrene contains up to 0.1% of the carbon in TMC-1.

Structure of 1-cyanopyrene

1-C16H9CN

Wenzel et al. 2024

Common Name: 1-cyanopyrene
Year Discovered: 2024
Source: TMC-1
Telescope: GBT
Fun Fact: It is estimated that pyrene contains up to 0.1% of the carbon in TMC-1.

Structure of 2-methoxyethanol

CH3OCH2CH2OH

Fried et al. 2024

Common Name: 2-methoxyethanol
Year Discovered: 2024
Source: NGC 6334I
Telescope: ALMA
Fun Fact: Largest oxygen-containing molecule detected outside of our Solar System.

Structure of indene

C9H8

Burkhardt et al. 2021

Common Name: indene
Year Discovered: 2021
Source: TMC-1
Telescope: GBT
Fun Fact: First pure hydrocarbon polycyclic aromatic hydrocarbon discovered in space

Structure of 1-cyanonaphthalene

1-C10H7CN

McGuire et al. 2021

Common Name: 1-cyanonaphthalene
Year Discovered: 2021
Source: TMC-1
Telescope: GBT
Fun Fact: First polycyclic aromatic hydrocarbon discovered in space (alongside 2-cyanonapthalane)

Structure of 2-cyanonaphthalene

2-C10H7CN

McGuire et al. 2021

Common Name: 2-cyanonaphthalene
Year Discovered: 2021
Source: TMC-1
Telescope: GBT
Fun Fact: First polycyclic aromatic hydrocarbon discovered in space (alongside 1-cyanonapthalane)

Structure of vinylcyanoacetylene

H2CCHC3N

Lee et al. 2021a

Common Name: vinylcyanoacetylene
Year Discovered: 2021
Source: TMC-1
Telescope: GBT

Structure of cyanovinylacetylene

HCCCHCHCN

Lee et al. 2021a

Common Name: cyanovinylacetylene
Year Discovered: 2021
Source: TMC-1
Telescope: GBT

Structure of 2-cyano-cyclopentadiene

2-C5H5CN

Lee et al. 2021b

Common Name: 2-cyano-cyclopentadiene
Year Discovered: 2021
Source: TMC-1
Telescope: GBT

Structure of 1-cyano-cyclopentadiene

1-C5H5CN

McCarthy et al. 2021

Common Name: 1-cyano-cyclopentadiene
Year Discovered: 2021
Source: TMC-1
Telescope: GBT
Fun Fact: First molecule containing a five-membered ring detected in space

Structure of HC11N

HC11N

Loomis et al. 2021

Common Name: Cyanopentaacetylene
Year Discovered: 2021
Source: TMC-1
Telescope: GBT

Structure of HC4NC

HC4NC

Xue et al. 2020

Common Name: Isocyanoacetylene
Year Discovered: 2020
Source: TMC-1
Telescope: GBT

Structure of propargyl cyanide

HCCCH2CN

McGuire et al. 2020

Common Name: Propargyl cyanide
Year Discovered: 2020
Source: TMC-1
Telescope: GBT

Structure of benzonitrile

C6H5CN

McGuire et al. 2018

Common Name: Benzonitrile
Year Discovered: 2018
Source: TMC-1
Telescope: GBT
Fun Fact: First molecule containing a benzene ring seen by radio astronomy

Structure of methoxymethanol

CH3OCH2OH

McGuire et al. 2017

Common Name: Methoxymethanol
Year Discovered: 2017
Source: NGC6334I
Telescope: ALMA
Fun Fact: Several orders of magnitude more abundant than predicted by models

Structure of HC5O

HC5O

McGuire et al. 2017

Common Name: Butadiynylformyl radical
Year Discovered: 2017
Source: TMC-1
Telescope: GBT

Structure of propylene oxide

CH3CHCH2O

McGuire & Carroll et al. 2016

Common Name: Propylene oxide
Year Discovered: 2016
Source: Sgr B2(N)
Telescope: GBT
Fun Fact: First chiral molecule discovered outside the solar system

Structure of carbodiimide

HNCNH

McGuire et al. 2012

Common Name: Carbodiimide
Year Discovered: 2012
Source: Sgr B2(N)
Telescope: GBT
Fun Fact: Discovered by maser transitions