This gallery highlights selected first interstellar detections by group members and collaborators. Each entry links to the paper describing the evidence. Together, these molecules trace our work from carbon chains and oxygen-bearing organics to individual polycyclic aromatic hydrocarbons (PAHs). A tentative identification is labeled explicitly and should not be read as a confirmed detection.

Following Molecules into New Environments

The first detection of a molecule is the beginning of its chemical story. We now compare aromatic populations across sources, including the 2026 detection of phenalene in MC27/L1521F, a cloud containing a very low-luminosity protostar. This was the first detection of a three-ring PAH outside TMC-1, rather than the first interstellar detection of phenalene itself. Our observational research page describes how these comparisons test the formation and survival of aromatic carbon.

Structure of cyanocoronene

C24H11CN

Wenzel et al. 2025

Common Name: Cyanocoronene
Year Discovered: 2025
Source: TMC-1
Telescope: GBT
Fun Fact: Seven fused rings and 25 carbon atoms; identified through its rotational spectrum in cold TMC-1.

Structure of 3-hydroxypropanal

HOCH2CH2CHO

Fried et al. 2025

Common Name: 3-hydroxypropanal (tentative)
Year Discovered: 2025
Source: G+0.693-0.027
Telescope: Yebes 40m Telescope and IRAM 30m Telescope
Fun Fact: Tentative identification of 3-hydroxypropanal toward G+0.693-0.027; confirmation requires further observational evidence.

Structure of 4-cyanopyrene

4-C16H9CN

Wenzel et al. 2025

Common Name: 4-cyanopyrene
Year Discovered: 2025
Source: TMC-1
Telescope: GBT
Fun Fact: One of three detected cyanopyrene isomers. Their relative abundances help test the chemistry linking CN radicals and pyrene.

Structure of 2-cyanopyrene

2-C16H9CN

Wenzel et al. 2025

Common Name: 2-cyanopyrene
Year Discovered: 2025
Source: TMC-1
Telescope: GBT
Fun Fact: The cyano group makes this pyrene derivative accessible to radio spectroscopy; the abundance of parent pyrene must be inferred chemically.

Structure of 1-cyanopyrene

1-C16H9CN

Wenzel et al. 2024

Common Name: 1-cyanopyrene
Year Discovered: 2024
Source: TMC-1
Telescope: GBT
Fun Fact: The first four-ring PAH identified in space. The detected molecule is 1-cyanopyrene, a cyano-substituted derivative of pyrene.

Structure of 2-methoxyethanol

CH3OCH2CH2OH

Fried et al. 2024

Common Name: 2-methoxyethanol
Year Discovered: 2024
Source: NGC 6334I
Telescope: ALMA
Fun Fact: A 13-atom oxygen-bearing organic molecule; laboratory spectroscopy enabled its identification with ALMA in NGC 6334I.

Structure of indene

C9H8

Burkhardt et al. 2021

Common Name: indene
Year Discovered: 2021
Source: TMC-1
Telescope: GBT
Fun Fact: First pure hydrocarbon polycyclic aromatic hydrocarbon discovered in space

Structure of 1-cyanonaphthalene

1-C10H7CN

McGuire et al. 2021

Common Name: 1-cyanonaphthalene
Year Discovered: 2021
Source: TMC-1
Telescope: GBT
Fun Fact: One of the first two individual interstellar PAHs identified by radio spectroscopy, alongside 2-cyanonaphthalene.

Structure of 2-cyanonaphthalene

2-C10H7CN

McGuire et al. 2021

Common Name: 2-cyanonaphthalene
Year Discovered: 2021
Source: TMC-1
Telescope: GBT
Fun Fact: One of the first two individual interstellar PAHs identified by radio spectroscopy, alongside 1-cyanonaphthalene.

Structure of vinylcyanoacetylene

H2CCHC3N

Lee et al. 2021a

Common Name: vinylcyanoacetylene
Year Discovered: 2021
Source: TMC-1
Telescope: GBT

Structure of cyanovinylacetylene

HCCCHCHCN

Lee et al. 2021a

Common Name: cyanovinylacetylene
Year Discovered: 2021
Source: TMC-1
Telescope: GBT

Structure of 2-cyano-cyclopentadiene

2-C5H5CN

Lee et al. 2021b

Common Name: 2-cyano-cyclopentadiene
Year Discovered: 2021
Source: TMC-1
Telescope: GBT

Structure of 1-cyano-cyclopentadiene

1-C5H5CN

McCarthy et al. 2021

Common Name: 1-cyano-cyclopentadiene
Year Discovered: 2021
Source: TMC-1
Telescope: GBT
Fun Fact: First molecule containing a five-membered ring detected in space

Structure of HC11N

HC11N

Loomis et al. 2021

Common Name: Cyanopentaacetylene
Year Discovered: 2021
Source: TMC-1
Telescope: GBT

Structure of HC4NC

HC4NC

Xue et al. 2020

Common Name: Isocyanodiacetylene
Year Discovered: 2020
Source: TMC-1
Telescope: GBT

Structure of propargyl cyanide

HCCCH2CN

McGuire et al. 2020

Common Name: Propargyl cyanide
Year Discovered: 2020
Source: TMC-1
Telescope: GBT

Structure of benzonitrile

C6H5CN

McGuire et al. 2018

Common Name: Benzonitrile
Year Discovered: 2018
Source: TMC-1
Telescope: GBT
Fun Fact: First molecule containing a benzene ring seen by radio astronomy

Structure of methoxymethanol

CH3OCH2OH

McGuire et al. 2017

Common Name: Methoxymethanol
Year Discovered: 2017
Source: NGC6334I
Telescope: ALMA
Fun Fact: Several orders of magnitude more abundant than predicted by models

Structure of HC5O

HC5O

McGuire et al. 2017

Common Name: Butadiynylformyl radical
Year Discovered: 2017
Source: TMC-1
Telescope: GBT

Structure of propylene oxide

CH3CHCH2O

McGuire & Carroll et al. 2016

Common Name: Propylene oxide
Year Discovered: 2016
Source: Sgr B2(N)
Telescope: GBT
Fun Fact: First chiral molecule discovered outside the solar system

Structure of carbodiimide

HNCNH

McGuire et al. 2012

Common Name: Carbodiimide
Year Discovered: 2012
Source: Sgr B2(N)
Telescope: GBT
Fun Fact: Discovered by maser transitions