Research in the McGuire Group at MIT asks how molecules form, react, and survive as interstellar clouds become stars and planets. We combine laboratory rotational spectroscopy, radio astronomy, chemical kinetics modeling, and machine learning to connect the molecules we observe with the chemistry that made them.
A major focus is the chemistry of polycyclic aromatic hydrocarbons (PAHs): molecules built from connected carbon rings that are thought to hold a substantial fraction of interstellar carbon. Our work with the GOTHAM collaboration has identified individual members of this population, from two-ring cyanonaphthalenes to seven-ring cyanocoronene. We can now ask which structures are favored, how they grow or break apart, and whether they form in cold clouds or arrive there from earlier generations of stars.
These questions move in both directions between the laboratory and the telescope. We synthesize and measure candidate molecules, search for their spectral fingerprints in space, and use detections and meaningful upper limits to test chemical models. We also develop tools to make those experiments and analyses faster, while checking where their predictions succeed and where they fail.
3 Dec 2025 - Gabi receives AAS LAD Early Career Award! (Read More)
23 Oct 2025 - GOTHAM team shares largest public molecular survey to-date (Read More)
1 May 2025 - The group detects a new seven ring PAH in space (Read More)
1 May 2025 - Hannah successfully defends Ph.D. Thesis! (Read More)
21 Nov 2024 - Zach F. receives 2024 ISMS Rao Prize! (Read More)
24 Oct 2024 - The group detects a new four ring PAH in space (Read More)