Research in the McGuire Group at MIT asks how molecules form, react, and survive as interstellar clouds become stars and planets. We combine laboratory rotational spectroscopy, radio astronomy, chemical kinetics modeling, and machine learning to connect the molecules we observe with the chemistry that made them.
A major focus is the chemistry of polycyclic aromatic hydrocarbons (PAHs): molecules built from connected carbon rings that are thought to hold a substantial fraction of interstellar carbon. Our work with the GOTHAM collaboration has identified individual members of this population, from two-ring cyanonaphthalenes to seven-ring cyanocoronene. We can now ask which structures are favored, how they grow or break apart, and whether they form in cold clouds or arrive there from earlier generations of stars.
These questions move in both directions between the laboratory and the telescope. We synthesize and measure candidate molecules, search for their spectral fingerprints in space, and use detections and meaningful upper limits to test chemical models. We also develop tools to make those experiments and analyses faster, while checking where their predictions succeed and where they fail.
23 July 2026 - Phenalene detected beyond TMC-1 (Read More)
27 May 2026 - Congratulations to Dr. Alex Byrne and Dr. Zach Fried! (Read More)
19 May 2026 - New opportunities for astrochemistry at Haystack (Read More)
17 April 2026 - Brett receives MIT’s Edgerton Faculty Achievement Award (Read More)
19 February 2026 - Brett named a Sloan Research Fellow (Read More)
3 December 2025 - Gabi receives AAS LAD Early Career Award! (Read More)
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